Title and theme
Popular belief dictates that the song title references an idea first conceived by Carl Jungand later expounded upon by Drunvalo Melchizedek concerning the possibility of reaching a state of evolution at which the body would have two more than the normal 46 totalchromosomes and leave a currently disharmonious state.[2][3] The premise is that humans would deviate from the current state of human DNA which contains 44 autosomes and 2sex chromosomes. The next step of evolution would likely result in human DNA being reorganized into 46 autosomes and 2 sex chromosomes, according to Melchizedek.
Furthermore, it is believed the song references a wish to experience change through the "shadow"; an idea which represents the parts of one's identity that one hates, fears, and represses, this exists as a recurring theme in the work of Carl Jung.[4]